Assignment for genes encoding the terminal complement components to porcine chromosome

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The three-way relationship of polymorphisms of porcine genes encoding terminal complement components, their differential expression, and health-related phenotypes

BACKGROUND The complement system is an evolutionary ancient mechanism that plays an essential role in innate immunity and contributes to the acquired immune response. Three modes of activation, known as classical, alternative and lectin pathway, lead to the initiation of a common terminal lytic pathway. The terminal complement components (TCCs: C6, C7, C8A, C8B, and C9) are encoded by the genes...

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Regional Assignment of Ptpre Encoding Protein Tyrosine Phosphataes ε to Mouse Chromosome 7F3

Protein tyrosine phosphatases (PTPases) regulate the tyrosine phosphorylation of target proteins in‌volved in several biological activities including cell proliferation and transformation. Protein tyrosine phosphatase E (PTPE) contains duplicated PTPase-like domains and a short extracellular region. Us‌ing the fluorescence in situ hybridization method, the gene encoding PTPE (locus symbol Ptpre...

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Role of the Terminal Complement Components

The mechanisms of the complement-mediated myocardial injury associated with ischemia and reperfusion have not been elucidated fully. Complement activation may directly mediate injury through actions of the anaphylatoxins C3a and C5a or generation of the membrane attack complex C5b-9. A model was developed to examine the direct effects of complement activation on heart function, assess myocardia...

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Assignment of three novel genes to porcine chromosome 13 by a radiation hybrid panel.

Pig is an important economical animal as its muscle serves as food in the everyday meat supply. Pork quality and quantity must associate with several genes, especially those expressed in the early stage of muscle development. In this study, we selected three novel genes in a porcine fetus skeletal muscle cDNA library and mapped them all to porcine chromosome 13 using IMpRH panels (Yerle et al.,...

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Assignment of 12 genes to porcine chromosome 1 by linkage and radiation hybrid mapping.

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ژورنال

عنوان ژورنال: Biotechnology in Animal Husbandry

سال: 2014

ISSN: 1450-9156,2217-7140

DOI: 10.2298/bah1403407a